Table 3.
Tertiary Referral Cohort Baseline Clinical and Echocardiographic Features by Sex
| Variable | Total (n=2824) | Men (n=2089) | Women (n=735) | P Value |
|---|---|---|---|---|
| Age, y | 51±16 | 52±16 | 49±16 | 0.0003 |
| BMI, kg/m2 | 28±10 | 28±9 | 27±12 | 0.02 |
| Weighted Charlson index | 1.39±2 | 1.40±2 | 1.38±2 | 0.82 |
| Ejection fraction, % | 61±9 | 60±10 | 63±8 | <0.0001 |
| Coarctation, n (%) | 149 (5) | 96 (5) | 53 (7) | 0.008 |
| Endocarditis, n (%) | 2 (0.07) | 2 (0.1) | 0 (0) | 0.97 |
| Aorta diameter, mma | 41±7 (n=2078) | 42±7 (n=1543) | 37±7 (n=535) | <0.0001 |
| Aneurysm (≥45 mm), n (%)a | 564 (27) | 491 (32) | 73 (14) | <0.0001 |
| Aorta diameter/height, mm/ma | 23±4 | 23.3±4 | 22.8±7 | 0.01 |
| Aorta cross‐section by height, cm2/ma | 7.6±2.5 | 7.8±2.5 | 6.9±2.5 | <0.0001 |
| Aortic peak velocity, m/s | 2.44±1.1 | 2.44±1.1 | 2.43±1.1 | 0.83 |
| Severe AS | 333 (12) | 243 (12) | 90 (12) | 0.64 |
| AR 2+, n (%) | 313 (11) | 248 (12) | 65 (9) | 0.02 |
| AR 3+, n (%) | 150 (5) | 129 (6) | 21 (3) | 0.0004 |
| AR 4+, n (%) | 227 (8) | 211 (10) | 16 (2) | <0.0001 |
| ESD for AR ≥2+, mmb | 39±8 (n=439) | 40±8 (n=371) | 35±7 (n=68) | <0.0001 |
| ESD/BSA for AR ≥2+, mm/m2 b | 19±4 | 19±4 | 20±4 | 0.44 |
AR indicates aortic regurgitation; AS, aortic stenosis; BMI, body mass index; BSA, body surface area; ESD, end‐systolic diameter.
a
Aorta diameter was available for 2078 (74%) (1543 men, 535 women) of 2824 patients; thus, aneurysm % are based on those denominators. Height in meters.
b
ESD diameter was available for 439 (64%) (371 men, 68 women) of 690 patients with AR ≥2+; thus, ESD/BSA are based on those denominators.