Table 7.
Independent Mortality Predictors for Entire Surgical Referral Cohort by Sexb
| Variable | Men | Women | ||
|---|---|---|---|---|
| Risk Ratio (95% CI) | P Value | Risk Ratio (95% CI) | P Value | |
| Age ≥60 y | 2.54 (1.85‐3.56) | <0.0001 | 2.99 (1.73‐5.58) | <0.0001 |
| Charlson indexa | 1.17 (1.11‐1.22) | <0.0001 | 1.12 (1.01‐1.22) | 0.02 |
| EF ≥50% | 0.68 (0.52‐0.89) | 0.006 | — | — |
| AR 4+ | 0.46 (0.22‐0.84) | 0.01 | 4.45 (1.004‐13.99) | 0.04 |
| NYHA 3 to 4 | 1.64 (1.28‐2.11) | <0.0001 | — | — |
AR indicates aortic regurgitation; EF, left ventricular ejection fraction; NYHA, New York Heart Association class.
a
Per unit change. Variables included in model: age ≥60 years, Charlson comorbidity index, BMI ≥30, ejection fraction ≥50%, severe AS, AR 4+, NYHA class 3 to 4, aortic diameter, baseline IE and known aortic coarctation.
b
When ESD/BSA was entered into the multivariate analysis, AR4+ lost statistical significance (P=0.71), and ESD/BSA became an independent predictor (HR 1.23; 95% CI 1.1‐1.39; P=0.0004 per unit change) for women only. Independent predictors remained unchanged for men.