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. 2016 Sep 30;5(10):e004228. doi: 10.1161/JAHA.116.004228

Figure 2.

Figure 2

Hepatic transcriptional responses to dietary cholesterol supplementation. Mice were fed regular chow or chow supplemented with cholesterol (0.15%) for up to 2.5 days. Gene expression analysis was conducted at days 0 and 2.5 (n=4 to 5 mice per time point). *P<0.05 vs WT. † P<0.05 vs 0 days on cholesterol, 1‐way repeated‐measures ANOVA. Abca1 indicates ATP‐binding cassette sub‐family A member 1; Abcg5/Abcg8, ATP‐binding cassette sub‐family G member 5/8; Cyp27a1, sterol 27 hydroxylase; Cyp7a1, cholesterol 7 alpha hydroxylase; Fasn, fatty acid synthase; Hmgcr, 3‐hydroxy‐3‐methyl‐glutaryl‐coenzyme A reductase; Ldlr, low density lipoprotein receptor; Mmp, matrix metalloproteinase gene; Nr1h3/Nr1h2, liver X receptor α/β; Pcsk9, proprotein convertase subtilisin/kexin type 9; Srebf1, sterol regulatory element binding protein 1; Srebf2, gene for sterol regulatory element binding protein 2; SREBP, sterol regulatory element binding protein; WT, wild type.