. 2016 Nov 24;7:1865. doi: 10.3389/fpsyg.2016.01865

Table 3.

Associations of haplotypes with total and spatial insight problem solving.

	Haplotype	Total insight problem solving						Spatial insight problem solving
		Frequencies (%)	B	t	R²	*p_emp1*	*p_emp2*	B	t	R²	*p_emp1*	*p_emp2*
Block 1^a	ACCT	39.2	0.022	0.091	0.000	0.755	1.00	0.002	0.00	0.000	0.976	1.00
	ACTC	31.3	0.115	2.48	0.006	0.115	0.614	0.094	1.65	0.004	0.206	0.820
	GCTC	17.9	−0.024	0.075	0.000	0.781	1.00	0.048	0.303	0.001	0.576	0.999
	ADTC	9.9	−0.231	4.45	0.010	0.038	0.257	−0.258	5.54	0.013	0.020	0.147
	Rare haplotypes	1.7
	Global test					0.118	0.217				0.114	0.213
Block 2^b	CCGGCCGCGC	41.8	−0.071	1.04	0.002	0.306	0.937	−0.054	0.598	0.001	0.453	0.989
	TTGTACAGTT	32.1	0.133	3.54	0.008	0.059	0.388	0.146	4.30	0.010	0.039	0.275
	CTGTACAGTT	8.5	0.183	2.46	0.006	0.117	0.617	0.196	2.80	0.007	0.092	0.543
	CTGGCCGCGC	6.6	−0.286	4.17	0.010	0.043	0.293	−0.242	2.97	0.007	0.085	0.506
	CTAGCTAGGC	5.4	−0.127	0.681	0.002	0.407	0.983	−0.182	1.41	0.003	0.239	0.875
	Rare haplotypes	5.7
	Global test					0.034	0.064				0.025	0.047

Haplotype frequencies were estimated using the expectation-maximization (EM) algorithm in Plink and linear regression was used to estimate haplotype-specific effect. An omnibus test was employed to obtain a global p value for the haplotype block. Empirical point-wise p-values (p_emp1) and multiple testing corrected p-values (p_emp2) were obtained by 10,000 permutations. Rare haplotypes (estimated frequency <5%) were excluded from the analysis.

The order of SNPs in block 1 was rs1799732, rs4938019, rs4648317, and rs4245418.

The order of SNPs in block 2 was rs4436578, rs7122246, rs2283265, rs1076560, rs6277, rs6276, rs6279, rs6278 and rs1800497. The significance p-values (<0.05) are indicated in bold.