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. 2016 Nov 24;6:37717. doi: 10.1038/srep37717

Figure 7. SATB1 participates in HBX-mediated fibrogenesis by modulation of IL-6, PDGF-AA and CTGF expression.

Figure 7

(a) The mRNA levels of SATB1, IL-6, PDGF-AA and CTGF were analyzed by Real-time PCR in L02 and PHC cells transduced with lenti-SATB1 and lenti-ctrl virus. (n = 3). *P < 0.05, **P < 0.01 vs. L02-Vector or PHC-Vector. (b) Silencing SATB1 in L02-HBx cells for 48 h, mRNA extracts were used for analyzing SATB1, IL-6, PDGF-AA, and CTGF expression by Real-time PCR. (n = 3). *P < 0.05, **P < 0.01 vs. L02-HBx NC. (c,d) Silencing SATB1 expression in L02-HBx cells for 48 h, the conditioned medium were used to determine the secretion amount of IL-6 and CTGF. (n = 3). *P < 0.05, **P < 0.01 vs. L02-HBx NC or L02-Vector NC.