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. 2016 Nov 24;6:35948. doi: 10.1038/srep35948

Table 2. Univariate and multivariate Cox regression analysis of prognostic factors in 246 HCC patients for overall survival.

Variable Univariate analysis
Multivariate analysis
HR 95% CI P-value HR 95% CI P-value
Overall survival
Age (years)
 >49 vs. ≤49 1.005 0.991–1.019 0.504      
Sex
 male vs. female 0.670 0.353–1.274 0.222      
AFP (ng/ml)
 ≥200 vs. <200 1.214 0.878–1.679 0.241      
Liver cirrhosis
 Positive vs. Negative 1.226 0.821–1.830 0.320      
Tumor size(cm)
 >5 vs. ≤5 1.704 1.200–2.421 0.003* 1.596 1.110–2.294 0.012*
Tumor multiplicity
 Multiple vs. Single 1.787 1.218–2.622 0.003* 1.864 0.831–4.183 0.131
Pathological grade
 III-IV vs. I-II 1.685 1.218–2.331 0.002* 1.604 1.145–2.248 0.006*
TNM stage
 III-IV vs. I-II 1.583 1.121–2.235 0.009* 0.961 0.580–1.593 0.879
BCLC stage
 B-C vs. 0-A 1.736 1.229–2.452 0.002* 0.774 0.324–1.852 0.565
Vascular invasion
 Positive vs. Negative 1.887 1.065–3.343 0.029* 2.035 0.849–4.881 0.111
GNA13 expression
 High vs. Low 1.676 1.187–2.366 0.003* 1.558 1.096–2.215 0.014*

*P < 0.05.