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. 2016 Nov 24;6:36856. doi: 10.1038/srep36856

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The effect of age was best described by a quadratic polynomial (age coefficient −0.14, SE 0.07; P = 0.033; age² coefficient 0.019; SE 0.007; P = 0.005). Component and residuals plot from a linear mixed effects model. The r² of the full model was 0.53; the r² of random effects was 0.40.