Figure 6. Schematic illustration showing the means by which Mint3 depletion attenuates inflammatory cytokine/chemokine production in IFV-infected macrophages.

Mint3 depletion both activates AMPK and promotes IκBα accumulation in macrophages. These mechanisms contribute to inhibiting the nuclear translocation of NF-κB and the resulting inflammatory cytokine/chemokine production in IFV-infected macrophages.