. 2016 Nov 24;6:37730. doi: 10.1038/srep37730

Table 3. Differentially expressed proteins identified by the iTRAQ analysis of B. odoriphaga that are related to the adaption response to benzothiazole.

No.	Accession ID	Description	Unique Peptide	Score	Coverage (%)	Fold change (Mean ± SD) BT/CON
	Amino acid transport and metabolism
26	gi\|54289246	pyrroline-5-carboxylate synthase, partial [Aedes aegypti]	2	213	4.5	1.802 ± 0.147
27	gi\|284159519	arginine kinase, partial [Coquillettidia perturbans]	2	908	18.1	1.783 ± 0.105
28	gi\|157129677	serine hydroxymethyltransferase [Aedes aegypti]	1	78	2.9	1.350 ± 0.112
29	gi\|524934116	putative aminopeptidase [Anopheles aquasalis]	2	172	4.2	0.524 ± 0.052
30	gi\|545916496	putative alanine aminotransferase [Corethrella appendiculata]	2	39	3.1	0.854 ± 0.173
	Carbohydrate transport and metabolism
31	gi\|157674465	putative enolase [Lutzomyia longipalpis]	2	1218	18.7	1.379 ± 0.096
32	gi\|545917538	putative transaldolase, partial [Corethrella appendiculata]	1	208	6.3	1.314 ± 0.233
33	gi\|563354904	pyruvate kinase [Mayetiola destructor]	8	928	17	1.201 ± 0.130
34	gi\|405132161	glycogen phosphorylase [Belgica antarctica]	3	248	5.5	0.841 ± 0.066
	Cell wall/membrane/envelope biogenesis
35	gi\|58376929	Glucosamine–fructose-6-phosphate aminotransferase [Anopheles gambiae]	1	165	3.7	0.853 ± 0.146
	Cytoskeleton
36	gi\|31210041	Actin-related protein 3 [Drosophila melanogaster]	4	284	12.9	0.749 ± 0.112
	Energy production and conversion
37	gi\|313482947	putative IgE binding protein, partial [Culicoides nubeculosus]	1	318	23.8	1.569 ± 0.607
38	gi\|158300600	Probable citrate synthase 1, mitochondrial [Aedes aegypti]	2	430	14.8	1.548 ± 0.185
39	gi\|157132308	ATP synthase beta subunit [Aedes aegypti]	13	2473	36.9	1.529 ± 0.064
40	gi\|563354932	malate dehydrogenase 1 [Mayetiola destrauctor]	6	200	16.9	1.519 ± 0.266
41	gi\|157123846	pyruvate carboxylase [Aedes aegypti]	9	233	7.5	1.310 ± 0.063
42	gi\|545919823	putative methylmalonate semialdehyde dehydrogenase [Corethrella appendiculata]	2	139	7.1	1.241 ± 0.135
43	gi\|108878452	ATP synthase subunit beta vacuolar [Aedes aegypti]	10	570	28.6	1.231 ± 0.083
	General function prediction only
44	gi\|56684613	ADP ribosylation factor 79 F [Aedes aegypti]	4	548	31.3	1.363 ± 0.192
45	gi\|545920491	putative g protein [Corethrella appendiculata]	5	234	13.2	1.355 ± 0.202
46	gi\|157136642	ras-related protein Rab-7 [Aedes aegypti]	3	130	15.4	1.184 ± 0.247
47	gi\|545918333	putative gtpase ran/tc4/gsp1 nuclear protein [Corethrella appendiculata]	5	328	28.5	1.156 ± 0.203
	Inorganic ion transport and metabolism
48	gi\|14906173	putative 3′-phosphoadenosine 5′-phosphosulfate synthetase, partial [Aedes aegypti]	1	44	4.2	1.592 ± 0.011
49	gi\|157131369	Na⁺/K⁺ ATPase alpha subunit [Aedes aegypti]	10	619	19.8	1.505 ± 0.226
	Intracellular trafficking, secretion, and vesicular transport
50	gi\|545918815	putative signal peptidase i [Corethrella appendiculata]	3	233	18.9	0.729 ± 0.086
	Lipid transport and metabolism
51	gi\|524934245	putative microtubule associated complex [Anopheles aquasalis]	3	110	13.2	1.262 ± 0.078
52	gi\|167874883	3-oxoacyl-[acyl-carrier-protein] reductase [Culex quinquefasciatus]	1	104	4.7	1.271 ± 0.318
	Posttranslational modification, protein turnover, chaperones
53	gi\|545920109	putative 60 kda heat shock protein mitochondrial [Corethrella appendiculata]	1	239	7.4	2.184 ± 0.233
54	gi\|108868487	Small ubiquitin-related modifier 3 [Aedes aegypti]	1	208	12.6	1.994 ± 0.868
55	gi\|157122974	prohibitin [Aedes aegypti]	5	144	18.4	1.976 ± 0.065
56	gi\|545916790	putative atp-dependent lon protease, partial [Corethrella appendiculata]	5	129	5.9	1.425 ± 0.366
57	gi\|2738077	heat shock protein 60 [Culicoides variipennis]	3	557	13.1	1.415 ± 0.105
58	gi\|157106603	26 S protease regulatory subunit S10b [Aedes aegypti]	5	273	13.2	1.393 ± 0.136
59	gi\|89212800	heat shock cognate 70 [Rhynchosciara americana]	13	1725	39	1.200 ± 0.040
60	gi\|157131453	26 S protease regulatory subunit [Aedes aegypti]	1	121	14.2	0.863 ± 0.151
61	gi\|108870669	Rab GDP-dissociation inhibitor [Aedes aegypti]	5	130	11.3	0.905 ± 0.103
	Replication, recombination and repair
62	gi\|167865143	ebna2 binding protein P100 [Culex quinquefasciatus]	2	96	2.6	0.806 ± 0.016
	Secondary metabolites biosynthesis, transport and catabolism
63	gi\|157115283	fatty acid synthase [Aedes aegypti]	2	295	1.9	1.835 ± 0.480
64	gi\|584594454	cytochrome P450 6FV2 [Chironomus kiiensis]	1	114	4.6	0.748 ± 0.190
	Signal transduction mechanisms
65	gi\|58396588	14-3-3 protein epsilon [Drosophila melanogaster]	6	1263	22.7	0.754 ± 0.050
66	gi\|94468532	myosin light chain [Aedes aegypti]	3	107	19.7	0.822 ± 0.023
	Transcription
67	gi\|58378742	Nascent polypeptide-associated complex subunit alpha [Drosophila melanogaster]	3	358	18	1.402 ± 0.156
	Translation, ribosomal structure and biogenesis
68	gi\|170030017	40 S ribosomal protein S23 [Culex quinquefasciatus]	2	338	15.4	1.681 ± 0.129
69	gi\|568255436	hypothetical protein AND_004054 [Anopheles darlingi]	2	91	3.4	1.668 ± 0.091
70	gi\|329669248	60 S acidic ribosomal protein P1 [Simulium guianense]	1	781	14.5	1.649 ± 0.204
71	gi\|29839631	60 S ribosomal protein L23 [Aedes aegypti]	4	538	31.4	1.584 ± 0.416
72	gi\|157674443	60 S acidic ribosomal protein P0-like protein [Lutzomyia longipalpis]	1	635	22.4	1.535 ± 0.103
73	gi\|58392254	60 S ribosomal protein L12 [Mus musculus]	3	160	18.2	1.433 ± 0.129
74	gi\|545920235	putative elongation factor 2, partial [Corethrella appendiculata]	2	623	12.8	1.155 ± 0.186
75	gi\|56809869	ribosomal protein S9 [Aedes albopictus]	6	189	23.1	0.697 ± 0.145
76	gi\|545920339	putative ribosomal protein l32 [Corethrella appendiculata]	3	436	16.4	0.739 ± 0.179
77	gi\|56199506	ribosomal protein L27A, partial [Culicoides sonorensis]	2	398	13.2	0.777 ± 0.046
78	gi\|401715292	60 s ribosomal protein L15, partial [Nyssomyia intermedia]	2	200	20.9	0.789 ± 0.287
79	gi\|157361525	40 S ribosomal protein S15-like protein [Phlebotomus papatasi]	3	299	23.1	0.806 ± 0.095
80	gi\|545920337	putative 60 s acidic ribosomal protein p0 [Corethrella appendiculata]	1	576	21.3	0.823 ± 0.240
81	gi\|269146822	60 s ribosomal protein L10, partial [Simulium nigrimanum]	2	179	11.4	0.879 ± 0.091
	Uncharacterized
82	gi\|157131827	tropomyosin invertebrate [Aedes aegypti]	1	176	25.2	4.289 ± 2.567
83	gi\|157127892	paramyosin, long form [Aedes aegypti]	1	146	3.9	3.158 ± 0.843
84	gi\|74920601	ADP, ATP carrier protein 2 [Anopheles gambiae]	1	628	24.3	2.057 ± 0.155
85	gi\|108884438	AAEL000311-PA [Aedes aegypti]	1	174	1.7	1.474 ± 0.411
86	gi\|407379599	gamma-glutamylcystein synthase [Chironomus riparius]	1	79	2.4	1.378 ± 0.166
87	gi\|167872478	mitochondrial processing peptidase beta subunit [Culex quinquefasciatus]	2	57	2.6	1.346 ± 0.305
88	gi\|404553129	prophenoloxidase 6, partial [Anopheles sinensis]	2	60	7.5	0.695 ± 0.052
89	gi\|157109554	titin [Aedes aegypti]	1	354	2.4	0.736 ± 0.095
90	gi\|157117953	glutamate cysteine ligase [Aedes aegypti]	1	112	2.3	0.805 ± 0.250
91	gi\|158295341	AGAP006103-PC [Anopheles gambiae]	1	202	7.5	0.850 ± 0.150
92	gi\|108884446	AAEL000339-PA [Aedes aegypti]	1	135	2.1	0.876 ± 0.155