Tryptophan- precursor to 5-HT |
Bifidobacterium infantis
|
Rats |
Aids in combating psychiatric disorders such as depression [84] |
|
Lactobacillus johnsonii
|
In vitro model |
Reduces serum kynurenine concentrations and IDO activity in vitro in HT-29 colonic cells, which prevents the breakdown of tryptophan [138] |
Serotonin |
Lactococcus lactis subsp. Cremoris (MG 1363), Lactococcus lactis subsp. Lactis (IL 1403), Lactobacillus plantarum (FI8595), Streptococcus thermophilus (NCFB2392), Eschericchia coli K-12, Morganella morganii (NCIMB, 10466), Klebisella pneumoniae (NCIMB, 673), Hafnia alvei (NCIMB, 11999) |
In vitro model |
Produce serotonin [47, 139] |
|
Butyrate and acetate produced by bacteria |
Mice |
Induce serotonin synthesis in a dose-dependent manner by regulating the gene Tph1 that synthesizes serotonin [68] |
Dopamine |
Bacillus cereaus, Bacillus mycoides, Bacillus subtilis, Proteus vulgaris, Serratia marcescens, S. aureus, E.col, E.coli K-12, Morganella morganii (NCIMB, 10466), Klebisella pneumoniae (NCIMB, 673), Hafnia alvei (NCIMB, 11999) |
In vitro model |
Produce dopamine [140–142] |
GABA |
Lactobacillus rhamnosus (JB-1)
|
Mice |
Regulates GABA receptor expression and reduced stress-induced corticosterone, anxiety and depression [143] |
|
Bifidobacterium dentium DPC6333, Bifidobacterium dentium NCFB2243, B. infantis UCC35624, Bifidobacterium adolescentis DPC6044, Lactobacillus brevis DPC6108, Bacillus mycoides, Bacillus subtiles, Proteus vulgaris, Lactobacillus rhamnosus YS9 |
Humans |
Lactobacillus brevis DPC6108 was the most effective at producing GABA [8]. |
Cortisol |
Lactobacillus helveticus R0052; Bacteroidetes longum R0175 |
Humans |
Reduce urinary free cortisol output [133, 144] |
Noradrenaline |
B. mycoides, B. subtilis, P. vulgaris, S. marescens, E. coli K-12 |
In vitro chromatography |
Regulates motility and secretions in the ENS. Elevated levels due to acute stress can cause the growth of pathogenic E. coli [140]. |