Table 1.

A list of unmet needs with brain volume as identified by the panel

Unmet Needs
1.	Applicability of MRI volume measurement in clinical practice
2.	Lack of large long-term prospective studies of clinical correlates with brain volume loss
3.	Reliable assessments of cognitive impairment in MS
4.	Validation of disease progression parameters with brain volume loss
5.	Lack of pathological correlation with brain volume loss
6.	Paucity of data on regional brain volume effect in MS
7.	Targeting brain volume loss as one of the main outcome measure in clinical trials
8.	Reproducible effectiveness of DMTs in phase III studies on cognitive impairment