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The tally of brain volume assessment
| How? | SIENA | SIENAx | BPF | VBM | |
| 12 | 4 | ||||
| In Whom? | RIS | CIS | RRMS | SPMS | |
| 7 | 11 | 12 | 4 | ||
| When? | Initial | 3–6 months | Anytime with MRI acquisition | 6–12 months | Annual |
| 3 | 2 | 11 | 1 | ||
| Who? | Neurologist | Radiologist | MRI Technician | Independent | |
| 1 | 12 | 1 |
Abbreviations: BPF (Brain Parenchymal Fraction), SIENA (Structural Image Evaluation, using Normalization, of Atrophy), SIENAx (Structural Image Evaluation, using Normalization, of Atrophy Cross-sectional), VBM (Voxel-Based Morphometry)
