Table 3.
Established and putative homologs of NCL proteins in other model organisms
| Human Protein |
S. cerevisiae (budding yeast) S. pombe (fission yeast) |
C. elegans (nematode) | D. melanogaster (fruit fly) | D. rerio (zebrafish) |
|---|---|---|---|---|
| PPT1/CLN1 Accession: NP_000301 |
Yes (S. pombe) [26–28] | Yes [26] | Yes [26–28] | Yes [27, 28] |
| TPP1/CLN2 Accession: NP_000382 |
No | No | No | Yes [27, 28] |
| CLN3 Accession: NP_000077 |
Yes [26–28] | Yes [26–28] | Yes [26–28] | Yes [27, 28] |
| DNAJC5/CLN4 Accession: NP_079495 |
Yes [a] | Yes [28] | Yes [c] | Yes [27, 28] |
| CLN5 Accession: NP_006484 |
No | No | No | Yes [27, 28] |
| CLN6 Accession: NP_060352 |
No | No | No | Yes [27, 28] |
| MFSD8/CLN7 Accession: NP_689991 |
No | Yes [b] | Yes [27, 28] | Yes [27, 28] |
| CLN8 Accession: NP_061764 |
No | No | No | Yes [27, 28] |
| CTSD/CLN10 Accession: NP_001900 |
Yes [26–28] | Yes [26, 28] | Yes [26–28] | Yes [27, 28] |
| PGRN/CLN11 Accession: NP_002078 |
No | Yes [b] | No | Yes [27, 28] |
| ATP13A2/CLN12 Accession: NP_071372 |
Yes [28],[a] | Yes [b] | Yes [c] | Yes [27, 28] |
| CTSF/CLN13 Accession: NP_003784 |
No | Yes [b] | Yes [c] | Yes [27, 28] |
| KCTD7/CLN14 Accession: NP_694578 |
No | Yes [b] | Yes [c] | Yes [27, 28] |