Table 4.

Localization of NCL homologs in Dictyostelium and other systems

Dictyostelium homolog	dictyBase ID	Localization in Dictyostelium	Localization of human protein (or homologs in other systems)
Ppt1	DDB0233890	Extracellular space [40] Macropinocytic pathway [32]	Cytoplasmic vesicles [21] Endoplasmic reticulum [21] Lipid rafts [21] Lysosomal matrix [21] Presynaptic areas in neurons [21]
Tpp1	DDB0234303	Lysosome [14]	Endoplasmic reticulum [21] Lysosomal matrix [21]
Cln3	DDB0233983	CV system [13, 15] Endocytic pathway [13, 15] Macropinocytic pathway [32]	Late endosomal membrane [21] Lysosomal membrane [21]
Ddj1	DDB0215016	Centrosome [69] Macropinocytic pathway [32] Phagosome [70]	Cell membrane [68] Cytoplasm [21] Melanosomes [67] Synaptic vesicles in neurons [21] Secretory granules in endocrine, neurocrine and exocrine cells [21] Vesicular membranes [21]
Cln5	DDB0234077	Macropinocytic pathway [32]	Extracellular space [76] Lysosomal matrix [21, 75]
Mfsd8	DDB0307149	Macropinocytic pathway [32]	Lysosomal membrane [21]
CtsD	DDB0215012	Endocytic pathway (e.g., phagosome, lysosome) [81–83] Macropinocytic pathway [32]	Extracellular space [21, 79, 80] Lysosomal matrix [21]
Grn	DDB0238428	Not known	Extracellular space [21, 97]
Kil2	DDB0237611	Macropinocytic pathway [32] Phagosomal membrane [102]	Lysosomal membrane [21, 99, 100] Multi-vesicular bodies [21, 99, 100]
CprA	DDB0201647	Not known	Lysosomal matrix [21]
Kctd9	DDB0231824	Not known	Cell membrane [21, 114] Punctate cytoplasmic distributions [21, 114]