Table 5.
Cellular processes modulated by NCL homologs in Dictyostelium and other systems
| Dictyostelium homolog | dictyBase ID | Processes modulated in Dictyostelium | Knockout mutant generated | Processes modulated by human protein (or homologs in other systems) |
|---|---|---|---|---|
| Ppt1 | DDB0233890 | Phagocytosis [41] | No | Apoptosis [21] Cholesterol metabolism [21] Phagocytosis [42] Recycling of synaptic vesicles [21] |
| Tpp1 | DDB0234303 | Autophagy [14] Pre-spore cell differentiation [14] Timing of mid-stage development [14] |
Yes [14] | Endocytosis [21] Macroautophagy [21] TNF-α-induced apoptosis [21] |
| Cln3 | DDB0233983 | Cell proliferation [13] Pinocytosis [13] Protein secretion and cleavage [13] Cell adhesion [15] Timing of mid-stage development [15] Timing of late-stage development [15] Response to bacterial pathogens [66] |
Yes [13] | Apoptosis [21] Autophagy [21] Calcium homeostasis [21] Cell cycle control [21] Endocytosis [21] Intracellular trafficking [21] Lysosomal pH homeostasis [21] Osmoregulation [21] |
| Ddj1 | DDB0215016 | Phagocytosis [70] | No | Presynaptic endocytosis and exocytosis [21] |
| Cln5 | DDB0234077 | Not known | No | Apoptosis [21] Cell growth [21] Myelination [21] Sorting and recycling of lysosomal receptors [21] Sphingolipid transport and synthesis [21] |
| Mfsd8 | DDB0307149 | Not known | No | Predicted to have a role in: Transport of small substrates across the lysosomal membrane [21] |
| CtsD | DDB0215012 | Bacterial killing [86] Cell death [88, 89] Timing of early-stage development [81] |
Yes [79] | Apoptosis [21, 90] Autophagy [21, 91] Cell migration [85] Innate immune response [87] |
| Grn | DDB0238428 | Not known | No | Autophagy [21, 97] Cell migration [21, 97] Embryogenesis [21, 97] Inflammation [21, 97] Tumorigenesis [21, 97] |
| Kil2 | DDB0237611 | Bacterial killing [102, 105] Predation on yeast [104] |
Yes [100] | Predicted to have a role in: Lysosomal degradation [21] pH and biometal homeostasis within lysosomes [21] Transport across cellular membranes [21] |
| CprA | DDB0201647 | Early-stage development [108] Osmoregulation [110] |
No | Autophagy [21] Cell immunity [21, 113] Lipoprotein degradation [21] Proteasome degradation [21] |
| Kctd9 | DDB0231824 | Not known | Yes [118] | Predicted to have a role in: Hyperpolarization of the neuronal cell membrane [21] Proteasome degradation [21] |