Table 4. Correlation of the mutation rate and variants frequency of top-4 mutated genes stratified by tumor AJCC stage and tumor location.
| AJCC stage | Tumor location | |||||||
|---|---|---|---|---|---|---|---|---|
| Stage 0-II | Stage III-IV | p value | Rectum | Left | Right | p value | ||
| n=30 | n=20 | n=15 | n=21 | n=14 | ||||
| Total genes | Tumor with mutation (%) | 90 | 85 | 0.594 | 93.3 | 85.7 | 85.7 | 0.749 |
| Variants frequency (%) | 40.2 ± 18.74 | 32 ± 20.4 | 0.046 | 33 ± 16.8 | 37.6 ± 19.0 | 40 ± 22.7 | 0.226 | |
| TP53 | Tumor with mutation (%) | 33.3 | 65 | 0.027 | 53.3 | 42.8 | 42.8 | 0.793 |
| Variants frequency (%) | 42.7 ± 18.8 | 41 ± 20.8 | 0.815 | 32 ± 12.5 | 48.4 ± 18.8 | 43 ± 24.9 | 0.239 | |
| KRAS | Tumor with mutation (%) | 46.6 | 40 | 0.641 | 53.3 | 47.6 | 28.5 | 0.369 |
| Variants frequency (%) | 42 ± 15.7 | 38 ± 25.4 | 0.692 | 31.9 ± 12.5 | 38 ± 17.6 | 62 ± 21.6 | 0.025 | |
| APC | Tumor with mutation (%) | 30 | 40 | 0.464 | 53.3 | 14.2 | 35.7 | 0.043 |
| Variants frequency (%) | 41.5 ± 20.1 | 35.1 ± 25.7 | 0.638 | 39.6 ± 24.4 | 25.6 ± 11.6 | 45.16 ± 20.8 | 0.421 | |
| PIK3CA | Tumor with mutation (%) | 23.3 | 25 | 0.892 | 13.3 | 19 | 42.8 | 0.139 |
| Variants frequency (%) | 31.8 ± 8.67 | 21.5 ± 5.9 | 0.031 | 29.5 ± 7.8 | 25.7 ± 8.3 | 27.7 ± 10.9 | 0.902 | |