Figure 9. Entinostat reduces the expression of DNMT1 and its combination with paclitaxel exerts more potent inhibitory effects on DNMT1 in vivo.

(A) Tumor tissues obtained from the animal studies (Figure 7) were homogenized to generate protein lysates. Equal amount of the total lysates from three tumors of each treatment group were used for western blot analysis of DNMT1 or β-actin. (B) DNMT1 signal intensities of the tumors were obtained by densitometry analyses. The average signal intensity of each group was shown. Bars, S.D.