Table 3. Predictive value of HELLS, ZIC2 and ZIC5 for biochemical recurrence after radical prostatectomy.
| Parameter | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | p-value | HR (95% CI) | p-value | |
| Age | 1.0 (1.0–1.09) | 0.04 | 1.0 (1.0–1.1) | 0.21 |
| PSA | 3.5 (2.3–5.3) | < 0.01 | 1.8 (1.1–2.8) | 0.03 |
| Gleason score | 2.5 (1.9–3.3) | < 0.01 | 1.8 (1.3–2.5) | < 0.01 |
| pT-stage | 1.7 (1.5–2.0) | < 0.01 | 1.3 (1.0–1.5) | 0.03 |
| Surgical margin | 3.3 (2.3–4.7) | < 0.01 | 2.3 (1.6–3.4) | < 0.01 |
| HELLS | 2.6 (1.7–4.0) | < 0.01 | 2.3 (1.5–3.6) | < 0.01 |
| ZIC2 | 1.1 (0.7–1.7) | 0.69 | 1.4 (0.9–2.2) | 0.11 |
| ZIC5 | 1.3 (0.9–1.9) | 0.15 | 0.9 (0.6–1.3) | 0.61 |
HR = Hazard ratio; CI = Confidence Interval; PSA = Prostate Specific Antigen.