Table 5. Univariate and multivariate results of PIWI genes.
| Parameter | Overall Survival | Recurrence Free Survival | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||
| HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | |
| Risk score (for OS) PIWIL3 (for RFS) | 2.82 (1.49 – 5.33) |
0.002 | 2.19 (1.14 – 4.22) |
0.02 | 2.07 (1.17 – 3.64) |
0.01 | 2.09 (1.18 – 3.71) |
0.01 |
| Tumor stage | 0.62 (0.24 – 1.57) |
0.31 | 0.56 (0.28 – 1.11) |
0.09 | ||||
| Tumor grade | 2.31 (1.1 – 4.83) |
0.03 | 1.75 (1.06 – 2.9) |
0.03 | ||||
| Age at diagnosis | 1.04 (1.02 – 1.07) |
0.001 | 1.04 (1.02 – 1.07) |
0.001 | 1.01 (0.99 – 1.03) |
0.22 | ||
| TNBC status | 3.33 (1.77 – 6.26) |
0.0002 | 2.35 (1.15 – 4.79) |
0.02 | 1.72 (1.07 – 2.79) |
0.03 | ||
HR = Hazards ratio, CI = Confidence interval
Table 5. Univariate analysis was performed, considering PIWI genes as continuous variables. Two PIWI genes were significant for OS with p ≤ 0.15 and were used for constructing a risk score, PIWIL3 alone was significant for RFS with p ≤ 0.15. Risk score for OS and PIWIL3 for RFS were considered as categorical variables and were found to be significant in univariate and multivariate analyses using Cox proportional hazards regression model.