Figure 2. Value of Ki67 and IRF-1 in predicting post LT HCC recurrence.
(A) Statistically significant differences among all the patients were obtained for RFS between negative and positive groups of Ki67 (P = 1.6 × 10−4, Bonferroni correction α′ = 1.5 × 10−3). (B) Difference in RFS between negative and positive groups of Ki67 in the patients with T1-T3a HCC (P = 6.8 × 10−4). (C) A significant correlation was obtained between Ki-67 and T stage in the primary, but not recurrent, HCC group (Spearman correlation R = 0.459, p = 1.2 × 10−5 and R = −0.139, P = 0.527). *: Extreme outliers. (D) A significant negative correlation was obtained between IRF-1 and Ki-67 (Spearman correlation R = −0.405, P = 0.030). ○: Mild outliers. (E) Among all the patients, differences in RFSs between negative and positive groups of IRF-1 failed to achieve statistical significance after Bonferroni correction (P = 0.023, Bonferroni correction α′ = 1.5 × 10−3). (F) In patients with HCCs beyond the Milan criteria, a significant difference in RFS was found between the negative and positive groups of IRF-1 (P = 6.4 × 10−5, Bonferroni correction α′ = 1.5 × 10−3).