Table 2. Univariate and multivariate analysis of HEY2 expression and outcomes of HCC patients in training cohort (n=351).
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Age (≤ 47 vs. > 47 years) | 0.796 (0.642-0.988) | 0.138 | ||
| Gender (female vs. male) | 0.846 (0.593-1.207) | 0.357 | ||
| HBsAg (positive vs. negative) | 1.175 (0.870-1.587) | 0.294 | ||
| Tumor size (≤ 5 vs. > 5 cm) | 1.374 (1.069-1.765) | 0.013 | 1.316 (1.007-1.719) | 0.045 |
| Tumor multiplicity (single vs. multiple) | 1.215 (0.974-1.517) | 0.085 | ||
| Tumor capsule | 0.648 (0.521-0.807) | 0.000 | 0.706 (0.558-0.895) | 0.004 |
| Liver cirrhosis (yes vs. no) | 0.698 (0.514-0.950) | 0.022 | 0.765 (0.558-1.048) | 0.095 |
| AFP (≤ 20 vs. > 20 ng/mL) | 1.388 (1.086-1.773) | 0.009 | 1.159 (0.899-1.495) | 0.254 |
| LNM (Yes vs. no) | 1.816 (1.213-2.717) | 0.004 | 1.588 (1.042-2.420) | 0.032 |
| Tumor differentiation | 1.431 (1.202-1.704) | 0.000 | 1.266 (1.055-1.521) | 0.011 |
| TNM (I vs. II vs. III vs. IV) | 1.237 (1.123-1.362) | 0.000 | 1.081 (0.967-1.209) | 0.172 |
| Vascular invasion (Yes vs. No) | 1.808 (1.393-2.346) | 0.000 | 1.215 (0.911-1.621) | 0.185 |
| HEY2 expression (low vs. high) | 1.753 (1.401-2.193) | 0.000 | 1.645 (1.309-2.067) | 0.000 |
HR, hazard ratio; CI, confident interval; AFP, alpha-fetoprotein; HBsAg, hepatitis B surface antigen; LNM, lymph node metastasis.