Table 1. INF-γ, TNF-α, CXCL2, IL-12, IL-6, IL-4, IL-10 and TGF-β mRNA transcripts in adherent and non-adherent granuloma cells from 3′RR-deficient mice and wt mice.
| Non-adherent cells | Adherent cells | |||||
|---|---|---|---|---|---|---|
| Cytokines | Wt mice | 3′RR-deficient mice | Significance | Wt mice | 3′RR-deficient mice | Significance |
| IL-10 | 102.2 ± 24.0 | 170.7 ± 184.6 | 1.0 | 18.3 ± 18.2 | 57 ± 59.5 | 0.7 |
| IL-4 | 22.3 ± 10.4 | 5.5 ± 3.0 | 0.1 | 187.6 ± 92.6 | 58.1 ± 68.8 | 0.2 |
| TGF-β | 10.0 ± 5.7 | 7.3 ± 4.8 | 0.8 | 18182.8 ± 13113.5 | 17473.4 ± 12895.2 | 1.0 |
| IL-6 | 104.6 ± 127.0 | 265.6 ± 451.4 | 1.0 | 12043.4 ± 15219.9 | 37439.7 ± 57409.8 | 1.0 |
| TNF-α | 21.4 ± 2.8 | 26.9 ± 32.9 | 0.4 | 432.6 ± 493.9 | 615.2 ± 585.8 | 0.6 |
| IL-12 | 736.5 ± 244.3 | 1448.1 ± 1346.8 | 0.6 | 1044.1 ± 1111.5 | 2038.1 ± 2411.3 | 1.0 |
| INF-γ | 41.0 ± 12.8 | 50.7 ± 34.0 | 0.6 | 64 ± 13.4 | 60.06 ± 72.6 | 1.0 |
| CXCL2 | 31.1 ± 15.3 | 43.3 ± 64.6 | 0.4 | 612.3 ± 704.4 | 543.3 ± 612.4 | 1.0 |
Gene expression levels were normalized to GAPDH mRNA. Amounts of transcripts were compared to sample with the lowest level of transcripts. Results are reported as Mean ± SEM from 4 independent experiments per group. Significance was assessed with the Mann-Whitney U-test. No significant differences were documented between groups.