Table 1. Major regulators of aerobic glycolysis in tumor.

Key modulators	Via	References
Abhd5	AMPK, GLUT1, HK I, HK II, LDHA, PKM1, p53	[37]
Caveolin 1	Akt-mTOR, GLUT3	[38–40]
CD147	MCT1, MCT4, p53	[41–43]
Ecdysoneless	GLUT4	[44]
FAK	LDH, MCT, PKM2	[45]
GRIM-19	HIF-1α, p53, STAT3, HK II, PDK1, PFK1, PKM2	[46]
GRP78	HIF-1α, PKM2	[47]
HIF-1α	GLUT1, HK II, PDK1, PKM2	[48–52]
HSP40	PKM2	[53]
KLF4	LDHA	[54]
K-Ras	GLUT1	[55]
KSHV	PKM2	[56]
LMP1	LDHA	[57]
miRNAs	GLUT1, GLUT3, HK II, LDHA, PFK, PFKFB3	[58–69]
p53	AMPK, GLUT1, GLUT3, GLUT4, G6PD, PGM, Pten, TIGAR, TSC2	[70–77]
P2×7	GLUT1, HIF-1α, PKM2	[78]
PI3K-Akt-mTOR	c-Myc, HIF-1α, NFκB GLUT1, GLUT3, HK II, LDHA, PFK, PKM2	[48, 79–83]
Skp2	Akt, GLUT1	[84]
Survivin	DNM1L	[85]
TRAP1	c-Src	[86]
Wnt	PDK1	[87]
ZBTB7A	GLUT3, PFKP, PKM	[88]