Table 4.
Exploratory analysis of risk factors for mortality at 6 months after onset of bronchiolitis obliterans syndrome (n = 75, with 31 deaths)
| Univariate |
Multivariate |
|||
|---|---|---|---|---|
| HR (95% CI) | P Value | HR (95% CI) | P Value | |
| FAM | 1.04 (0.4–2.7) | 0.94 | —– | —– |
| Slope FEV1, % predicted greater than −0.30/mo | 0.61 (0.3–1.3) | 0.21 | —– | —– |
| Diagnosis 0–1 yr post-HCT | 1.97 (0.9–4.1) | 0.07 | 2.30 (1.0–5.1) | 0.04 |
| FEV1 <44% predicted | 2.12 (1.0–4.4) | 0.04 | 1.40 (0.6–3.1) | 0.40 |
| FVC, % <67% predicted | 2.36 (1.2–4.8) | 0.02 | 2.67 (1.2–6.0) | 0.02 |
| Myeloablative conditioning | 0.54 (0.3–1.1) | 0.09 | 0.59 (0.3–1.2) | 0.12 |
Definition of abbreviations: CI = confidence interval; FAM = fluticasone, azithromycin, montelukast study cohort; HCT = hematopoietic cell transplant; HR = hazard ratio.