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Proposed algorithm for the initiation of SSc-ILD (systemic sclerosis–associated interstitial lung disease)–targeted therapy. *We consider a clinically significant decline in FVC as greater than 10% and a decline in DlCO (diffusing capacity of the lung for carbon monoxide) as greater than 15%, in the absence of pulmonary hypertension. HRCT = high-resolution computed tomography; PFTs = pulmonary function tests.
