Table 3.

Mean changes (in absolute value) from baseline, with 95% confidence intervals, at 6, 12, 18, and 24 months: FVC % predicted, Dl_CO % predicted, Dl_CO/Va % predicted, TLC, mRSS, and TDI by treatment group^*

	CYC		MMF		ΔMMF – ΔCYC
	Change	95% CI	Change	95% CI	Δ	95% CI
FVC % predicted
6 mo	0.40	−0.9 to 1.7	0.94	−0.4 to 2.3	0.54	−1.3 to 2.4
12 mo	2.10	0.60 to 3.60†	2.31	0.84 to 3.78†	0.21	−1.9 to 2.3
18 mo	3.16	1.69 to 4.64†	2.54	1.12 to 3.96†	−0.62	−2.7 to 1.4
24 mo	2.88	1.19 to 4.58†	2.19	0.53 to 3.84†	−0.70	−3.1 to 1.7
TLC % predicted
6 mo	0.11	−1.34 to 1.56	1.37	−0.16 to 2.85	1.26	−0.9 to 3.4
12 mo	0.80	−0.71 to 2.3	0.99	−0.51 to 2.50	0.19	−2.0 to 2.3
18 mo	1.49	−0.30 to 3.29	0.62	−1.16 to 2.39	−0.87	−3.4 to 1.6
24 mo	0.45	−1.43 to 2.32	1.24	−0.68 to 3.18	0.80	−2.0 to 3.6
DlCO % predicted
6 mo	−3.54	−5.4 to –1.7†	0.12	−1.7 to 2.0	3.67	1.1 to 6.3
12 mo	−3.15	−5.1 to –1.2†	1.84	−0.08 to 3.76	4.99	2.2 to 7.8
18 mo	−2.17	−4.2 to –0.12†	1.09	−0.88 to 3.06	3.26	0.41 to 6.1
24 mo	−2.14	−4.59 to 0.31	−0.40	−2.81 to 2.01	1.74	−1.6 to 5.1
DlCO/Va % predicted
6 mo	−5.90	−7.6 to –4.2†	−1.03	−2.7 to 0.7	4.88	2.5 to 7.3†
12 mo	−5.94	−7.7 to –4.1†	−0.03	−1.8 to 1.8	5.90	3.4 to 8.4†
18 mo	−4.62	−6.5 to –2.7†	1.09	−0.88 to 3.1	3.26	0.40 to 6.1†
24 mo	−3.43	−5.7 to –1.2†	−2.46	−4.7 to –0.2†	0.96	−2.2 to 4.1
TDI
6 mo	0.32	−0.4 to 1.1	0.87	0.13 to 1.60†	0.54	−0.5 to 1.6
12 mo	0.89	0.12 to 1.67†	0.87	0.11 to 1.64†	−0.02	−1.1 to 1.1
18 mo	1.46	0.57 to 2.40†	0.88	−0.03 to 1.8	−0.58	−1.9 to 1.0
24 mo	2.16	1.14 to 3.18†	1.77	0.75 to 2.79†	−0.39	−1.8 to 1.0
mRSS
6 mo	−1.57	−2.8 to 0.3	−0.83	−2.0 to 0.34	0.75	−0.9 to 2.4
12 mo	−3.57	−4.9 to –2.†	−3.33	−4.7 to –2.0†	0.24	−1.7 to 2.2
18 mo	−4.49	−5.8 to –3.2†	−4.25	−5.5 to –3.0†	0.25	−1.6 to 2.1
24 mo	−5.35	−6.9 to –3.8†	−4.90	−6.4 to –3.4†	0.45	−1.7 to 2.6
QLF-WL‡	1.13	−1.71 to 3.98	2.15	−0.72 to 5.03	1.02	−2.99 to 5.03
QLF-LM‡	−0.27	−1.43 to 1.69	0.12	−1.02 to 1.26	0.39	−1.27 to 2.05
QILD-WL‡	−1.84	−5.16 to 1.46	−0.95	−4.1 to 2.2	0.89	−3.58 to 5.36
QILD-LM‡	−2.78	−5.17 to –0.40†	−2.51	−4.9 to –0.15†	0.27	−3.09 to 3.67

Definition of abbreviations: Δ = change; CI = confidence interval; CYC = cyclophosphamide; Dl_CO = diffusing capacity of the lung for carbon monoxide; Dl_CO/Va = ratio of Dl_CO to alveolar volume; MMF = mycophenolate mofetil; mRSS = modified Rodnan skin (skin thickness) score; QILD-LM = quantitative interstitial lung disease score-lobe of most involvement; QILD-WL = quantitative interstitial lung disease score-whole lung; QLF-LM = quantitative lung fibrosis score-lobe of most involvement; QLF-WL = quantitative lung fibrosis score-whole lung; TDI = transitional dyspnea index.

^*With between-treatment differences based on estimates from the joint model from Scleroderma Lung Study II (63).

^†P < 0.05.

^‡At 24 months.