Table 4.
Patient- and hospital-level factors associated with receipt of vasopressin in septic shock
| OR | 95% CI | P Value | |
|---|---|---|---|
| Patient characteristics | |||
| Age, yr | |||
| <50 | Ref | — | — |
| 50–64 | 0.96 | (0.94–0.99) | 0.01 |
| 65–74 | 0.90 | (0.88–0.93) | <0.001 |
| ≥85 | 0.71 | (0.69–0.74) | <0.001 |
| Female vs. male | 0.95 | (0.93–0.96) | <0.001 |
| Race | |||
| White | Ref | — | — |
| African American | 1.05 | (1.02–1.07) | <0.001 |
| Other | 1.00 | (0.98–1.03) | 0.95 |
| Primary insurance provider | |||
| Private | Ref | — | — |
| Medicare | 0.95 | (0.96–0.97) | <0.001 |
| Medicaid | 0.89 | (0.87–0.92) | <0.001 |
| Other/unknown | 0.95 | (0.92–0.99) | 0.01 |
| Year of admission | |||
| 2008 | Ref | — | — |
| 2009 | 1.07 | (1.03–1.10) | <0.001 |
| 2010 | 1.15 | (1.11–1.19) | <0.001 |
| 2011 | 1.47 | (1.42–1.52) | <0.001 |
| 2012 | 1.54 | (1.49–1.60) | <0.001 |
| 2013 | 1.60 | (1.54–1.66) | <0.001 |
| Comorbid disease | |||
| Each additional comorbidity* | 0.97 | (0.96–0.97) | <0.001 |
| Organ dysfunction | |||
| Cardiovascular | 2.56 | (2.51–2.60) | <0.001 |
| Respiratory | 3.25 | (3.20–3.31) | <0.001 |
| Neurologic | 0.99 | (0.97–1.01) | 0.37 |
| Hematologic | 1.62 | (1.60–1.65) | <0.001 |
| Renal | 1.75 | (1.72–1.78) | <0.001 |
| Hepatic | 1.98 | (1.93–2.03) | <0.001 |
| Major surgical admission† versus medical admission | 1.34 | (1.31–1.37) | <0.001 |
| ICU admission | 1.44 | (1.39–1.48) | <0.001 |
| Hospital-level characteristics | |||
| No. of beds | |||
| 500+ | Ref | — | — |
| 400–499 | 0.77 | (0.53–1.11) | 0.16 |
| 300–399 | 0.78 | (0.56–1.11) | 0.17 |
| 200–299 | 0.57 | (0.41–0.79) | 0.001 |
| 100–199 | 0.57 | (0.41–0.80) | 0.001 |
| <100 | 0.28 | (0.19–0.41) | <0.001 |
| U.S. Region | |||
| Midwest | Ref | — | — |
| South | 1.10 | (0.86–1.41) | 0.45 |
| Northeast | 1.39 | (1.02–1.38) | 0.04 |
| West | 2.03 | (1.51–2.72) | <0.001 |
| Urban location | 1.23 | (0.97–1.56) | 0.08 |
| Teaching hospital | 1.28 | (1.02–1.61) | 0.03 |
| AMOR | 2.65 | (2.48–2.84) |