Table 1. The complexity-adjusted (adjusted-R²) goodness-of-fit for each QTc formulae considering a linear, quadratic and cubic spline models of the relationship between weighted-mean of QTc and age-group.

			Men							Women
	Linear		Quadratic		Cubic-Spline			Linear		Quadratic		Cubic-Spline
	Adjusted-R2	P-Value	Adjusted-R2	P-Value	Adjusted-R2	P-Value		Adjusted-R2	P-Value	Adjusted-R2	P-Value	Adjusted-R2	P-Value
QTcBZT	0.66	< 0.001	0.62	0.003	0.72	0.012		0.12	0.128	0.05	0.318	0.13	0.339
QTcDMT	0.80	< 0.001	0.78	< 0.001	0.84	0.002		0.48	0.005	0.43	0.023	0.49	0.078
QTcFRD	0.88	< 0.001	0.87	< 0.001	0.91	< 0.001		0.74	< 0.001	0.72	< 0.001	0.74	0.008
QTcFRM	0.86	< 0.001	0.85	< 0.001	0.88	< 0.001		0.74	< 0.001	0.71	< 0.001	0.75	0.008
QTcHDG	0.90	< 0.001	0.91	< 0.001	0.94	< 0.001		0.78	< 0.001	0.76	< 0.001	0.77	0.006
QTcRTHa	0.87	< 0.001	0.86	< 0.001	0.90	< 0.001		0.64	< 0.001	0.61	0.004	0.63	0.026

P-values are F-tests comparing each model to a null model (i.e., no relationship between age and QTc). QTcBZT: QTc proposed by Bazett; QTcDMT: QTc proposed by Dmitrienko; QTcFRD: proposed by Fridericia; QTcFRM: QTc proposed by Framingham; QTcHDG: QTc proposed by Hodges; QTcRTHa: QTc proposed by Rautaharju.