Table 1. Selected single nucleotide polymorphisms with evidence for association with sudden cardiac death and ventricular fibrillation due to coronary artery disease.
Gene | rsID | Chromosome locus | Most severe consequence | OR (95% CI) | Reference |
NOS1AP | rs10918859 | 1q21 | Intron variant | Westaway, et al.[58] | |
rs12084280 | 1q23 | Intergenetic variant | |||
CASQ2 | rs7521023 rs17500488 rs3010396 rs7366407 |
1p13 1q13 1q13 1q13 |
3 prime UTR Variant Intron variant Intron variant Intergenic variant |
2.72 (1.44−5.13) | Refaat, et al.[79] Westaway, et al.[58] |
ACYP2 | rs1559040 | 2p16 | Intron variant | 1.54 (1.32−1.79) | Aouizerat, et al.[66] |
ZNF385B | rs16866933 | 2q31 | Intron variant | 1.69 (1.48−1.93) | Aouizerat, et al.[66] |
rs4621553 | 5q22 | Intergenic variant | 1.40 (1.24−-1.58) | ||
RAB3GAP1 | rs6730157 | 2q21 | Intron variant | 1.60 | Huertaz-Vazquez, et al.[74] |
SCN5A | rs11720524 | 3p22 | Intron variant | 1.35 (1.05−1.74) | Albert, et al;[57]
Marcsa, et al.[80] |
GPD1L | rs9862154 | 3q22 | Upstream gene variant | Westaway, et al.[58] | |
AGTR1 | rs263936 | 3q24 | Intergenic variant | 1.13 (1.04−1.22) | Aouizerat, et al.[66] |
GRIA1 | rs12189362 | 5q33 | Intron variant | 1.50 (1.32−1.69) | Aouizerat, et al.[66] |
ZNF365 | rs2077316 | 10q21 | Intron variant | 2.41 | Huertaz-Vazquez, et al.[74] |
GPC5 (GLYPIAN 5) | rs3864180 | 13q31 | Intron variant | 0.85 (0.74−0.98) | Arking, et al.[65] |
AP1G2 | rs2281680 | 14q11 | Splice region variant | 1.38 (1.23−1.54) | Aouizerat, et al.[66] |
rs11624056 | 14q31 | Intergeneic variant | 1.43 (1.26−1.62) | ||
DEGS2 | rs7157599 | 14q32 | Missense variant | 1.13 (1.08−1.19) | Aouizerat, et al. [66] |
rs17718586 | 17q24 | Intergeneic variant | 1.53 (1.32−1.78) | ||
rs597503 | 18p11 | Upstream gene variant | 1.45 (1.27−1.65) | ||
CXADR | rs2824292 | 21q21 | Intergeneic variant | 1.78 (1.47−2.13) | Bezzina, et al.[37] |
KCTD1 | rs16942421 | 18q11 | Intron variant | 1.68 (1.43−1.98) | Aouizerat, et al. [66] |
OR: odds ratio; UTR: untranslated region.