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. 2016 Nov 25;6:151. doi: 10.3389/fcimb.2016.00151

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Copyright © 2016 Ma, Cheng, Ying, Liu, Ma, Zhang, Liu, Zhang, Ye, Zhang, Xu, Wang and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histopathological analysis of the spleens from peptide-immunized mice after challenge with HTNV by H&E staining. (A) The GP6 peptide-immunized group. (B) The NP1 peptide-immunized group. (C) The inactivated Hantavirus vaccine group. (D) The PBS control group. (E) The adjuvant control. Red arrows show diffused lymphocyte infiltration, diffused hemorrhaging and increased white pulp in the spleens of two control groups.