Table 2.
Genotype distribution for GPX1 rs1050450 and SEPP1 rs3877899 polymorphisms and baseline characteristics according to genotype
| Genotype | N (%) | Age, years (median and range) | Sex (females/males) | BMI (median and range) | Plasma Se, µg/L (median and range) | Plasma Sepp1 ng/mL (median and range) * |
|---|---|---|---|---|---|---|
| GPX1 rs1050450 | ||||||
| Pro/Pro | 39 (41 %) | 33.0 (18.0–60.0) | 1.29 (22/17) | 22.9 (18.0–33.1) | 63.3 (34.3–109.1) | 3.9 (0.9–26.4) |
| Pro/Leu | 35 (37 %) | 37.0 (18.0–58.0) | 1.06 (18/17) | 23.7 (17.9–31.1) | 62.7 (35.8–103.2) | 4.2 (1.3–36.0) |
| Leu/Leu | 21 (22 %) | 34.0 (18.0–58.0) | 1.33 (12/9) | 24.6 (20.1–34.9) | 62.5 (37.2–96.2) | 3.6 (1.0–6.4) |
| SEPP1 rs3877899 | ||||||
| Ala/Ala | 46 (48 %) | 33.0 (20.0–58.0) | 0.92 (22/24) | 23.4 (18.7–31.1) | 66.3 (37.2–106.1)a | 3.1 (1.0–26.9) |
| Ala/Thr | 29 (31 %) | 33.0 (18.0–58.0) | 1.90 (19/10) | 22.9 (17.9–27.7) | 68.9 (34.3–96.2)a | 4.2 (0.9–36.0) |
| Thr/Thr | 20 (21 %) | 36.5 (18.0–60.0) | 1.22 (11/9) | 23.7 (18.9–34.9) | 52.0 (35.8–109.1)a | 4.3 (1.1–23.4) |
* Skewed data; for these parameters, p values (one-way ANOVA) were calculated for log-transformed data
a p for linear trend = 0.04