Table 4.
Selectively suppressive effect of selenium supplementation at the level of mRNA expression (relative expression, normalized to GAPDH). Data presented regardless of genotype
| Gene | Mean and SD, measured at four different time points | p value, (MANCOVA)* | |||
|---|---|---|---|---|---|
| Baseline | 2 weeks | 6 weeks | Washout | ||
| GPX1 | 1.425 ± 0.212a | 1.411 ± 0.187a | 1.355 ± 0.194 b | 1.292 ± 0.208 c | p < 0.0001 |
| GPX4 | 1.355 ± 0.217a | 1.294 ± 0.189 b | 1.284 ± 0.193 b | 1.251 ± 0.206 c | p = 0.002 |
| TRXR1 | 1.742 ± 0.226 | 1.721 ± 0.197 | 1.748 ± 0.195 | 1.736 ± 0.208 | p = 0.60 |
| SEPP1 | 1.555 ± 0.292a,c | 1.590 ± 0.316a,b | 1.620 ± 0.284a,b | 1.467 ± 0.318a,c | p = 0.001 |
| SEP15 | 1.625 ± 0.179a | 1.579 ± 0.181 b | 1.526 ± 0.165 c | 1.536 ± 0.223 c | p < 0.001 |
| SELS | 2.039 ± 0.274a | 1.977 ± 0.245a | 1.916 ± 0.217 b | 1.886 ± 0.309 b | p < 0.0001 |
| SELW | 1.220 ± 0.218a | 1.183 ± 0.218a,b | 1.115 ± 0.213 b | 1.125 ± 0.250 b | p = 0.0003 |
| SBP2 | 1.470 ± 0.212 | 1.476 ± 0.183 | 1.472 ± 0.233 | 1.493 ± 0.210 | p = 0.73 |
Statistically significant p values and mean values significantly different as compared to baseline expression are typed in bold. Values indexed with different upper case letters (a, b, c, d) are significantly different at p ≤ 0.05 (contrast test for different time points, adjusted for age, sex, BMI, and baseline plasma Se)
* Model adjusted for age, sex, BMI, and baseline plasma Se