Table 2. Overall and Subgroup Analyses and Heterogeneity of SP110 Gene Polymorphisms with the Risk of TB.
| Variables | n† | Allelic models | Homozygote comparisons | Heterozygote comparisons | Dominant models | Recessive models | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI)* | I2 (%) | p value | OR (95% CI)* | I2 (%) | p value | OR (95% CI)* | I2 (%) | p value | OR (95% CI)* | I2 (%) | p value | OR (95% CI)* | I2 (%) | p value | ||
| rs9061 | A vs. G | AA vs. GG | AG vs. GG | AA+AG vs. GG | AA vs. AG+GG | |||||||||||
| Overall | 7 (5) | 1.28 (1.14, 1.44) | 0 | <10−4 | 2.84 (1.84, 4.38) | 33 | <10−5 | 1.23 (1.05, 1.43) | 13 | 0.009 | 1.32 (1.14, 1.53) | 0 | <10−3 | 2.26 (1.18, 4.34) | 71 | 0.01 |
| All in HWE | 6 (4) | 1.31 (1.15, 1.49) | 0 | <10−4 | 2.32 (1.46, 3.69) | 0 | <10−3 | 1.34 (1.11, 1.60) | 0 | 0.002 | 1.42 (1.19, 1.69) | 0 | <10−4 | 1.47 (1.11, 1.95) | 44 | 0.008 |
| High quality | 5 (5) | 1.31 (1.17, 1.48) | 0 | <10−5 | 2.84 (1.84, 4.38) | 33 | <10−5 | 1.23 (1.05, 1.43) | 13 | 0.009 | 1.32 (1.14, 1.53) | 0 | <10−3 | 2.26 (1.18, 4.34) | 71 | 0.01 |
| Sample size | ||||||||||||||||
| >500 | 4 (4) | 1.31 (1.16, 1.48) | 0 | <10−4 | 2.93 (1.81, 4.73) | 49 | <10−4 | 1.25 (1.06, 1.46) | 22 | 0.006 | 1.33 (1.14, 1.55) | 0 | <10−3 | 2.28 (1.04, 4.98) | 77 | 0.04 |
| <500 | 3 (1) | 1.13 (0.82, 1.55) | 0 | 0.46 | 2.45 (0.88, 6.82) | NA | 0.09 | 0.94 (0.50, 1.77) | NA | 0.85 | 1.19 (0.67, 2.11) | NA | 0.55 | 2.49 (0.91, 6.83) | NA | 0.08 |
| rs1135791 | C vs. T | CC vs. TT | CT vs. TT | CC+CT vs. TT | CC vs. CT+TT | |||||||||||
| Overall | 10 (7) | 0.99 (0.84, 1.18) | 70 | 0.95 | 0.76 (0.57, 1.02) | 29 | 0.07 | 0.95 (0.75, 1.21) | 71 | 0.69 | 0.94 (0.74, 1.19) | 73 | 0.61 | 0.80 (0.64, 1.07) | 28 | 0.13 |
| All in HWE | 9 (6) | 1.04 (0.87, 1.24) | 67 | 0.68 | 0.75 (0.55, 1.02) | 40 | 0.07 | 1.02 (0.81, 1.30) | 64 | 0.84 | 1.01 (0.79, 1.30) | 69 | 0.94 | 0.78 (0.58, 1.06) | 38 | 0.11 |
| High quality | 8 (6) | 1.01 (0.82, 1.25) | 7 | 0.92 | 0.71 (0.49, 1.02) | 37 | 0.06 | 0.96 (0.72, 1.28) | 75 | 0.78 | 0.95 (0.71, 1.27) | 77 | 0.72 | 0.76 (0.53, 1.09) | 38 | 0.14 |
| Ethnicity | ||||||||||||||||
| Asian | 9 (6) | 1.01 (0.82, 1.23) | 74 | 0.94 | 0.71 (0.49, 1.02) | 37 | 0.06 | 0.96 (0.72, 1.28) | 75 | 0.78 | 0.95 (0.71, 1.27) | 77 | 0.72 | 0.76 (0.53, 1.09) | 38 | 0.14 |
| Sample size | ||||||||||||||||
| >500 | 7 (5) | 0.91 (0.77, 1.09) | 71 | 0.31 | 0.73 (0.47, 1.14) | 51 | 0.17 | 0.81 (0.71, 0.92) | 29 | 0.001 | 0.80 (0.70, 0.90) | 34 | <10−3 | 0.76 (0.52, 1.09) | 50 | 0.13 |
| <500 | 3 (2) | 1.46 (1.07, 1.98) | 0 | 0.02 | 1.12 (0.16, 8.04) | 0 | 0.91 | 1.80 (1.23, 2.63) | 0 | 0.003 | 1.80 (1.23, 2.63) | 0 | 0.003 | 0.88 (0.56, 1.41) | 0 | 0.60 |
| rs11556887 | T vs. C | TT vs. CC | TC vs. CC | TT+TC vs. CC | TT vs. TC+CC | |||||||||||
| Overall | 8 (4) | 1.10 (0.90, 1.34) | 70 | 0.35 | 1.32 (0.93, 1.85) | 6 | 0.12 | 1.26 (0.85, 1.87) | 81 | 0.26 | 1.32 (0.88, 2.00) | 83 | 0.18 | 1.23 (1.02, 1.48) | 0 | 0.03 |
| High quality | 6 (4) | 1.16 (0.94, 1.44) | 75 | 0.17 | 1.32 (0.93, 1.85) | 6 | 0.12 | 1.26 (0.85, 1.87) | 81 | 0.26 | 1.32 (0.88, 2.00) | 83 | 0.18 | 1.23 (1.02, 1.48) | 0 | 0.03 |
| Ethnicity | ||||||||||||||||
| Asian | 6 (2) | 1.11 (0.83, 1.50) | 66 | 0.47 | 2.76 (0.97, 7.89) | 0 | 0.06 | 1.56 (1.20, 2.02) | 0 | <10−3 | 1.61 (1.25, 2.07) | 0 | <10−3 | 2.59 (0.91, 7.39) | 0 | 0.07 |
OR, odds ratio; CI, confidence interval; TB, tuberculosis; HWE, Hardy-Weinberg equilibrium; SP110, Speckled 110.
I2, value of I2 for heterogeneity test; p value, p value of the Z test for overall effect.
*A random-effect model was used when I2 >50%; otherwise, a fixed-effect model was used, †Figure before the bracket is the number of studies for allele model; figure in the bracket is the number of studies for other four model.