Fig. 1. The effect of PDGF-bb on cell proliferation and miR-379 expression in VSMCs. (A) PDGF-bb promotes cell proliferation of VSMCs in a concentration-dependent (10–30 ng/mL) manner as measured by CCK-8 assay. (B) PDGF-bb promotes cell proliferation of VSMCs in a time-dependent (24–72 h) manner as measured by CCK-8 assay. (C) Expression of miR-379 on qRT-PCR is down-regulated after treatment with different concentrations of PDGF-bb. (D) Expression of miR-379 on qRT-PCR is down-regulated after treatment with different durations of PDGF-bb. Data represent the mean values of three independent replicates±SEM; significant differences relative to control group are shown as ^*p<0.05, ^**p<0.01, ^***p<0.001. PDGF-bb, platelet-derived growth factor-bb; VSMCs, vascular smooth muscle cells; qRT-PCR, quantitative real-time PCR; SEM, standard error of the mean.