Fig. 2. The effect of miR-379 on cell proliferation, invasion, migration, and apoptosis of VSMCs. Twenty-four hours after cells were transfected with miR-379 mimics, miR-379 inhibitor, or their respective controls, (A) cell proliferation of VSMCs was measured by CKK-8 assay; (B) cell invasion ability of VSMCs was measured by transwell assay (40×); (C) migration ability of VSMCs was measured by wound healing assay (40×); and (D) cell apoptosis of VSMCs was measured by flow cytometry. Data represent the mean values of three independent replicates±SEM; significant differences relative to control group are shown as ^*p<0.05, ^**p<0.01. VSMCs, vascular smooth muscle cells; SEM, standard error of the mean.