Table 4. Angiographic Characteristics between the Two Groups.
| Variables, n (%) | Entire patients | Matched patients | ||||
|---|---|---|---|---|---|---|
| Diltiazem (n=842) | Dual (n=1899) | p value | Diltiazem (n=811) | Dual (n=811) | p value | |
| Quantitative coronary angiography | ||||||
| MLD (mm) | 0.6±0.3 | 0.7±0.3 | 0.452 | 0.6±0.3 | 0.6±0.3 | 0.440 |
| Diameter narrowing (%) | 70.3±12.4 | 70.7±13.0 | 0.494 | 70.4±12.5 | 71.3±12.7 | 0.144 |
| RVD (mm) | 2.3±0.9 | 2.4±0.5 | 0.096 | 2.3±0.9 | 2.3±0.5 | 0.855 |
| Acetylcholine dose | ||||||
| A1 (20 ug) | 41 (4.8) | 109 (5.7) | 0.354 | 41 (5.0) | 55 (6.7) | 0.141 |
| A2 (50 ug) | 268 (31.8) | 689 (36.3) | 0.023 | 263 (32.4) | 273 (33.6) | 0.598 |
| A3 (100 ug) | 533 (63.3) | 1100 (57.9) | 0.009 | 507 (62.5) | 483 (59.5) | 0.222 |
| Spasm site | 2 (0.2) | 4 (0.2) | NS | 2 (0.2) | 2 (0.2) | 1.000 |
| Left arterial descending | 799 (94.8) | 1778 (93.6) | 0.198 | 768 (94.6) | 772 (95.1) | 0.650 |
| Left circumflex | 274 (32.5) | 762 (40.1) | <0.001 | 271 (33.4) | 275 (33.9) | 0.834 |
| Spasm location | 3 (0.3) | 8 (0.4) | NS | 3 (0.3) | 2 (0.2) | 1.000 |
| Proximal | 380 (45.1) | 929 (48.9) | 0.067 | 366 (45.1) | 365 (45) | 0.960 |
| Mid | 771 (91.5) | 1721 (90.6) | 0.429 | 743 (91.6) | 736 (90.7) | 0.540 |
| Distal | 684 (81.2) | 1547 (81.4) | 0.887 | 661 (81.5) | 656 (80.8) | 0.751 |
| Diffuse spasm* | 723 (85.8) | 1632 (85.9) | 0.960 | 697 (85.9) | 698 (86.0) | 0.943 |
| Multi-vessel spasm | 235 (27.9) | 665 (35) | <0.001 | 232 (28.6) | 246 (30.3) | 0.446 |
| EKG change | 41 (4.8) | 119 (6.2) | 0.150 | 40 (4.9) | 34 (4.1) | 0.475 |
| ST-segment elevation | 12 (1.4) | 42 (2.2) | 0.172 | 12 (1.4) | 11 (1.3) | 0.834 |
| ST-segment depression | 11 (1.3) | 47 (2.4) | 0.050 | 11 (1.3) | 12 (1.4) | 0.834 |
| T-inversion | 10 (1.1) | 20 (1.0) | 0.755 | 10 (1.2) | 5 (0.6) | 0.195 |
| Atrial fibrillation | 8 (0.9) | 10 (0.5) | 0.205 | 7 (0.8) | 6 (0.7) | 0.781 |
| Chest pain | 534 (63.4) | 1274 (67) | 0.062 | 521 (64.2) | 503 (62.0) | 0.354 |
| AV block | 285 (33.8) | 388 (20.4) | <0.001 | 276 (34.0) | 179 (22.0) | <0.001 |
MLD, minimum luminal diameter (during acetylcholine provocation test); RVD, reference vessel diameter (after nitroglycerin injection); EKG, echocardiogram; AV, atrioventricular.
*Narrowing length >30 mm.