Figure 5.

Effect of tissue swelling on vessel perfusion. (A) Representative immunofluorescence staining sections for hyaluronan (HA) and collagen (scale bar 100 μm), (B) typical immunofluorescence staining sections for lectin and CD31 (scale bar 100 μm), (C) area fraction of collagen and HA, and (D) swelling stress for the control and treated tumors tested. Changes in stress between the control and each of the treated groups are statistically significant (P < .05) for both tumor types. (E) Fraction of perfused vessels as a function of tumor swelling showing their exponential decay relationship (dash line, y = −27.22e^(−21.49x), R² = 0.8913) and also the different mechanism of collagen reduction to improve perfusion (dash circle).