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. 2016 Nov 18;10:92. doi: 10.3389/fncir.2016.00092

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Copyright © 2016 Hernández, Hernández, Perez de la Mora, Gómora, Fuxe, Eiden and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Elevated plus maze (EPM) performance after AVP magnocellular system upregulation induced by 24-h water deprivation (WD, 24 h). Under basal conditions, no differences in the time spent in the open arms were observed between MS and control (animal facility reared, AFR) rats. One way ANOVA with Bonferroni Post hoc test, showed that WD 24 h induced a significant reduction in the time spent in the open arm in both AFR and MS groups (^*^*^*p < 0.001 for WD (24 h) compared to basal, for each of the two groups AFR and MS). Reduction in time spent in open arms following WD (24 h) was significantly greater in the MS compared to the AFR group (^*^*^*p < 0.001).