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. 2016 Nov 25;9:130. doi: 10.3389/fnmol.2016.00130

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Copyright © 2016 Ramaker, Cargill, Swanson, Quirindongo, Cassar, Kretzschmar and Copenhaver.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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APPL holoprotein is concentrated in an amphisome-like compartment in GV1 cells and EP cells. (A,B) Examples of Manduca GV1 cells that were fixed and immunolabeled with a combination of antibodies against different Rab proteins (shown in green) and APPL (only anti-cAPPL is shown; magenta). Both anti-Rab7 (A) and anti-Rab11 (B) co-label a population of large cytoplasmic vesicles containing APPL holoprotein (arrowheads), similar to the vesicles found in developing neurons. (C,D) Examples of migrating EP cells in fixed embryos (60 HPF) that were immunolabeled with the same combinations of antibodies. Both anti-Rab7 (C) and anti-Rab11 (D) co-label the large cytoplasmic vesicles containing APPL holoprotein (arrowheads). Scale bar = 7 μm.