TABLE 3.
Cell surface receptor levels of human c-MET and EGFR on several tumor cell lines from various indications
Keratinocytes (NHEK.f-c.) were used to evaluate EGFR-related skin toxicity, and the liver cell line HepG2 was used for c-MET-mediated liver toxicity. Receptor surface level values are presented as mean molecules per cell of triplicates with S.D. values given in percentages. ACA, adenocarcinoma; CA, carcinoma.
| Cell line | Origin | c-MET receptor surface level × 103 ± S.D.% | EGFR receptor surface level × 103 ± S.D.% |
|---|---|---|---|
| A431 | Epidermoid CA | 14.7 ± 0.2 | 661.0 ± 1.4 |
| A549 | Lung ACA | 18.0 ± 0.6 | 39.3 ± 0.6 |
| EBC-1 | Lung SCC | 261.6 ± 1.1 | 62.2 ± 1.1 |
| HepG2 | Hepatocellular CA | 11.1 ± 1.4 | 1.3 ± 4.7 |
| KP-4 | Pancreatic CA | 7.7 ± 0.5 | 50.8 ± 0.9 |
| MDA-MB-468 | Breast ACA | 14.2 ± 1.0 | 1825.5 ± 0.1 |
| MKN-45 | Gastric ACA | 171.7 ± 1.0 | 45.4 ± 0.3 |
| NCI-H1975 | Lung ACA | 35.5 ± 0.7 | 37.8 ± 0.7 |
| NCI-H441 | Lung ACA | 52.2 ± 0.8 | 46.6 ± 3.7 |
| NCI-H596 | Lung ACA | 6.7 ± 1.0 | 148.5 ± 1.4 |
| NHEK.f-c. | Keratinocytes | 7.1 ± 8.9 | 128.7 ± 8.7 |
| T47D | Breast ACA | 0.0 | 13.2 ± 0.9 |