Table 2. Long-term activity measurements; Mean (SEM).
| Genotype | BW (g) | Food Intake (g) | Water intake (ml) | Ambulatory Time (sec/min) | Bursts of stereotypic activity (per min) | Horizontal counts (per min) | Ambulatory counts (per min) | Bursts of vertical activity (per min) | CW rotations (per min) | CCW rotations (per min) | Fat mass (g) | Lean mass (g) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mc4rK314X/K314X | 509.53*,† (10.99) | 34.61*,† (1.38) | 47.41*,† (2.45) | 2.72† (0.1) | 2.75*,† ±0.05 | 16.46*,† (0.95) | 9.10*,† (0.68) | 0.03 (0.01) | 0.27*,† (0.01) | 0.26*,† (0.01) | 191.07*,† (6.23) | 355.49† (10.11) |
| Mc4r+/K314X | 361.13 (12.10) | 24.69 (2.15) | 36.98 (1.69) | 3.34 (0.11) | 3.45 ±0.08 | 23.22 (0.94) | 12.83 (0.65) | 0.05 (0.01) | 0.35 (0.01) | 0.35 (0.01) | 67.98 (6.34) | 323.2 (5.74) |
| Mc4r+/+ | 360.88 (15.59) | 23.44 (1.54) | 35.17 (1.98) | 3.04 (0.17) | 3.36 ±0.09 | 24.32 (0.66) | 13.49 (0.56) | 0.06 (0.01) | 0.32 (0.02) | 0.32 (0.02) | 56.16 (2.04) | 337.31 (6.31) |
Male rats homozygous (Mc4rK314X/K314X, n = 8) or heterozygous (Mc4r+/K314X, n = 8) for non-functional melanocortin 4 receptor (MC4R), or wild-type rats (Mc4r+/+, n = 8).
CW: clockwise; CCW: counter-clockwise.
*significantly different from Mc4r+/+; †significantly different from Mc4r+/K314X; p < 0.05.