Figure 4. Effect of CK2 inhibitor on expression of DNM2.
(A,B) The CK2 inhibitor, TBB, suppresses DNM2 expression in ALL cells as assessed by q-PCR (A) and by western blot (B). (C,D) CK2 knockdown15 suppresses DNM2 expression in Nalm6 B-ALL (C) and CEM T-ALL (D) cells by q-PCR. (E,F) Ikaros knockdown rescues the TBB-induced change in DNM2 in Nalm6 B-ALL (E) and CEM T-ALL (F) cells. Compared with siCTL + TBB in D and E: *P < 0.05; **P < 0.01.