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. 2016 Nov 25;6:37499. doi: 10.1038/srep37499

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Copyright © 2016, The Author(s)

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(A) the MVD in tumor tissue is significantly decreased in mice of LV-SH-BMP2 group as compared with those in CON group and LV-SH-CON group. (B) the MVD in tumor tissue is significantly increased in mice of overexpression-LV-BMP2 group as compared with those in CON group and overexpression-LV-CON group. Notes: BMP-2: Bone morphogenetic protein 2; MVD: microvessel density; LV-SH-BMP2: lentivirus vectors expressing small hairpin RNA against BMP-2 gene. *Indicates P < 0.05 as compared with other groups.