Figure 4. Measurements of isometric force of pulmonary artery in the sham-operated, and rats with flow-induced pulmonary hypertension.
(A) Contraction responses of pulmonary artery to KCl (40 mM) and maximal concentration of phenylephrine (PE, 10−5 M). (B) Contraction responses of pulmonary artery to cumulative addition of phenylephrine (PE, 10−9 to 10−5 M). (C) Sensitivity of pulmonary contraction response to phenylephrine shown by % contraction. Results were analyzed using two-way RM ANOVA, and data are presented as mean ± SD. n = 6 different animals in each group. *P < 0.05 compared with AV fistula ligation.