Table 5.
Families showing slight evidence for linkage of myopia (Model 1) to chromosome 12q or 18p
| AMISH FAMILIES | |||||
| FAMILY ID | TWO-POINT LOD | MULTIPOINT | |||
| Marker | Zmax | LOD | NPL | P value | |
| 3061 | D12S1706 | 1.04 | 1.04 | * | N/A |
| D12S346 | 1.04 | 1.04 | * | N/A | |
| D12S78 | 1.04 | 1.04 | * | N/A | |
| 3049 | D18S474 | 1.14 | 1.27 | 2.19 | 0.02 |
| 3053 | D18S474 | 1.30 | 1.30 | -* | N/A |
| 3064 | D18S63 | 1.30 | 1.30 | -* | N/A |
| JEWISH FAMILIES | |||||
| FAMILY ID | TWO-POINT LOD | MULTIPOINT | |||
| Marker | Zmax | LOD | NPL | P value | |
| 20 | D12S79 | 1.12 | 1.12 | 3.45 | 0.02 |
| D12S86 | 1.12 | 1.12 | 3.45 | 0.02 | |
| 58 | D12S1706 | 1.16 | 1.16 | 3.01 | 0.06 |
| D12S346 | 1.16 | 1.16 | 3.01 | 0.06 | |
| 78 | D12S85 | 1.07 | 1.07 | 3.38 | 0.01 |
* Only single affected parent-offspring pairs were genotyped in these families so the NPL analysis was uninformative in these families. However, the parametric LOD score analysis that uses both affected and unaffected family members was informative for linkage.