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. 2016 Nov 25;6:37840. doi: 10.1038/srep37840

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The positions of those residues in human PRPF3 indicated in the figures, which correspond to the same residues in Prp3 of Saccharomyces cerevisiae S288c (NP_010761.3) respectively by MSA of PRPF3 from Homo sapiens to yeast. (a) Both amino acid H (yellow) and R (yellow) play a key role in Prp3 (purple)-U4/U6 snRNA duplex (brown) interaction.(b) The residues (pointed out by red open arrows)of Prp3 (purple) are important in protein-protein interaction.