Figure 2.

Up-regulation of RFC3 is associated with poor prognostic phenotype in breast cancer.

(A) RFC3 expression level in different differentiation stage (benign tissue, carcinoma in situ, invasive carcinoma) analyzed by immunohistochemistry. (B) Expression levels of RFC3 in 30 paired breast cancer and adjacent non-tumor breast tissues. Alteration of expression is shown as box plot presentations and the mean level of RFC3 expression in breast cancer were significantly higher than that in non-tumor tissues. (P < .0001, independent t test). Expression levels of RFC3 between 127 BCs with and without metastasis. The mean level of RFC3 expression in BCs with metastasis was significantly higher than that in BCs without metastasis (P < .0001, independent t test). (C) Overall survival, disease-free survival and metastasis-free survival rate for cases with high RFC3 expression versus that of cases with low RFC3 expression.