Table 2.
Cox regression analyses for contribution of various potential prognostic factors to survival in BC patients.
| Variable factors | Disease-free survival HR(95%CI) | P value | Overall survival HR(95%CI) | P value | Metastasis-free survival HR(95%CI) | P value |
|---|---|---|---|---|---|---|
| Univariate analysis | ||||||
| RFC3 expression (high vs low) | 4.484 (1.695-13.864) | .003 | 4.154 (1.889-9.136) | <.001 | 14.515 (4.985-42.263) | <.001 |
| Age (≥49 vs <49) | 1.016 (0.975-1.059) | .455 | 1.006 (0.974-1.040) | .708 | 0.997 (0.965-1.029) | .843 |
| Tumor size (≥2 cm vs <2 cm) | 2.770 (1.294-5.927) | .009 | 2.535 (1.081-5.943) | .032 | 3.168 (1.455-6.899) | .004 |
| Nodel status (positive vs negative) | 3.732 (1.921-7.250) | <.001 | 3.313 (1.617-6.788) | <.001 | 4.138 (2.038-8.042) | <.001 |
| Ki67 expression (positive vs negative) | 0.996 (0.460-2.154) | .991 | 0.945 (0.408-2.191) | .896 | 1.105 (0.485-2.522) | .812 |
| Histologic grade (I/II vs III) | 0.821 (0.408-1.651) | .58 | 1.186 (0.572-2.460) | .646 | 0.758 (0.358-1.604) | .468 |
| Multivariate analysis | ||||||
| RFC3 expression (high vs. low) | 11.646 (4.772-28.420) | <.001 | 5.037 (2.184-11.622) | <.001 | 20.429 (6.743-61.892) | <.001 |
| Tumor size (≥2 cm vs <2 cm) | 1.346 (0.414-4.373) | .622 | 0.839 (0.319-2.207) | .722 | 1.051 (0.409-2.699) | .918 |
| Nodel status (positive vs negative) | 7.265 (3.154-16.738) | .000 | 3.444 (1.365-8.687) | .009 | 8.773 (3.552-21.669) | <.001 |
Analysis was conducted on 127 cases. HRs (95% CI) and P values were calculated using univariate or multivariate Cox proportional hazard regression.