Circulating eCB levels in patients with PWS compared with healthy controls, in two different cohorts. Plasma levels of AEA (A, D), 2-AG (B, E), and AA (C, F), adjusted for age, sex, BMI (Israeli; A–C), or BMI-Z (North American; D–F), and race (North American; D–F) are shown as back-transformed adjusted mean ± 95% confidence interval in two different cohorts. *P < 0.05 relative to healthy controls of the same cohort.