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. 2016 Oct 22;5(12):1187–1199. doi: 10.1016/j.molmet.2016.10.004

Figure 2.

Figure 2

Disrupted energy balance in Magel2-null mice. As measured by indirect calorimetry over a 24 h period at 21 weeks of age, STD-fed Magel2-null mice exhibited abnormalities in TEE (A, B), FO (C, D), and CHO (E, F). These changes were not related to their ambulatory activity (G, H), but to their ability to run on a wheel, a corresponding measurement of voluntary activity (I, J). Similar patterns of results were obtained both in male (left panels) and female (right panels) mice. Legend: black bars, wild-type; white bars, Magel2-null mice. Data represent the mean ± SEM from 5 to 15 mice per group. *P < 0.05 relative to wild-type controls of the same sex.